|
KMID : 0525720160210010006
|
|
Journal of Chitin and Chitosan
2016 Volume.21 No. 1 p.6 ~ p.13
|
|
|
Preparation and Characterization of Microspheres using Chitosan and Polyvinypyrrolydone (PVP)
|
|
Choi Chang-Yong
Hong Woong-Gil
Jeong Gyeong-Won
Lee Hyun-Su
Choi Sun-Ju
Kim Won-Seok
Nah Jae-Woon
|
|
|
Abstract
|
|
|
|
The oral drug delivery system using polymeric micelle was limited due to its instability caused by the gastric acid and various enzymes. To overcome these problems, we prepared chitosan/PVP (Polyvinypyrrolydone) (CPM) microspheres according to the stirring speed by W/O emersion method. The physicochemical characterization of CPMs were analyzed by scanning electron microscope (SEM), dynamic light scattering (DLS), thermo-gravimetric analyzer (TGA) and FT-IR, The SEM results showed that the morphology of CPM was fine spherical shape. Furthermore, SEM and DLS results showed that the size and surface area of CPM were decrease to the increment of stirring speed. The thermal stability of CPM was enhanced than raw chitosan andPVP. These results revealed that CPMs are expected to good candidate in the oral delivery system fields.
|
|
|
KEYWORD
|
|
|
Chitosan, PVP, Chitosan/PVP microsphere, Oral delivery system
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|